Sounds like you might benefit from something like the UHK[1].

It's got tenting, which approaches that natural tilt to your hands, and there are several mouse add-ons to choose from, I'm sure one of them will suit your needs.

[1]https://uhk.io/

Yeah, something like that is awfully appealing. I don't have as much trouble with typing as with trackpadding for whatever happy combination of reasons, the biggest being that I taught myself to type after playing piano for many years first, and so completely ignored "proper" home-row typing in favor of piano-like "move your hand around and wiggle your fingers" typing. I'm still one of the faster typists I know, so doing it "wrong" hasn't held me back at all.

But. If my hands start to hurt while typing, I'm definitely trying something like that as my first keyboard experiment.