I went sort of this route in an experiment with Claude.. I really want Python for .NET but I said, damn the expense, prioritize .NET compatibility, remove anything that isn't supported feasably. It means 0 python libs, but all of NuGet is supported. The rules are all signatures need types, and if you declare a type, it is that type, no exceptions, just like in C# (if you squint when looking at var in a funny way). I wound up with reasonable results, just a huge trade of the entire Python ecosystem for .NET with an insanely Python esque syntax.

Still churning on it, will probably publish it and do a proper blog post once I've built something interesting with the language itself.

IronPython -> TitaniumPython?