But... why not just run macOS in a VM?

If/since AI agents work continuously, it seems like running macOS in a VM (via the virtualization framework directly) is the most secure solution and requires a lot less verification than any sandboxing script. (Critical feature: no access to my keychain.)

AI agents are not at all like container deploys which come and go with sub-second speed, and need to be small enough that you can run many at a time. (If you're running local inference, that's the primary resource hog.)

I'm not too worried about multiple agents in the same vm stepping on each other. I give them different work-trees or directory trees; if they step over 1% of the time, it's not a risk to the bare-metal system.

Not sure if I'm missing something...

1 limitation is Apple Virtualisation does not offer USB passthrough for connecting to iPhones for iOS development.