The point of saying and writing things is to be understood by your audience.

If I know a given wording is widely misunderstood, to the point I'm planning to immediately follow it with a clarification - often that's a sign it's not a very good wording.

There are exceptions, of course - go ahead and say Cephalopods (things like octopuses and squid) if you're a marine biology educator.

I am pretty sure the term "synergistic" is widely used among laymen as well in the context of supplements and medications.

So yeah, sure, context does matter.