Every so often when I'm doing refactoring work and my list of worries has decreased to the point I can start thinking of new things to worry about, I worry about how as we reduce the accidental complexity of code and condense the critical bytes of the working memory tighter and tighter, how we are leaning very hard on very few bytes and hoping none of them ever bitflip.

I wonder sometimes if we shouldn't be doing like NASA does and triple-storing values and comparing the calculations to see if they get the same results.

Might be worth doing the kind of "manual ECC" you're describing for a small amount of high-importance data (e.g., the top few levels of a DB's B+ tree stored in memory), but I suspect the biggest win is just to use as little memory as possible, since the probability of being affected by memory corruption is roughly proportional to the amount you use.