Anecdotal, but I asked Claude the other day about how to dilute my medication (HCG) and it flat out refused and started lecturing me about abusing drugs.

I copy and pasted into ChatGPT, it told me straight away, and then for a laugh said it was actually a magical weight loss drug that I'd bought off the dark web... And it started giving me advice about unregulated weight loss drugs and how to dose them.

If you had created a project with custom instructions and/ or custom style I think you could have gotten Claude to respond the way you wanted just fine.