We didn't do multi-region deployments, but we did store database backups in a separate region just in case something really bad happened and our AWS region became unavailable. Also had a plan/some ready Terraform stuff in order to start setting up a deployment if it became apparent that the region wasn't coming back anytime soon.

IMO, if you're using AWS and not replicating your data somewhere else, this should be an eye-opener for you.

Not sure why everyone read this as me doing anything here, I'm a fractional CTO, which is kind of an advisor. Nothing invaluable will be lost tho. It's not the core platform, just a localized version for specific customers in the region.