Unless you intend to build "industrial real-time 3D applications like employee training, product configurators and embedded systems." In which case you must use the Industry License, for which you must pay "Custom pricing."

I last looked into the matter when considering RFP's for government contracts for VR software. Didn't feel like haggling with Unity's sales reps, especially since the government hasn't been the greatest client of late.

All of this is before you get to the Asset Store, which largely seems to assume that gamedevs are the customers. I'd rather not re-read the license agreement for every asset I've bought, but I know for certain that a number of them are explicitly games-only.