Unfortunately, many Qwerty typing guides group keys in left-leaning columns [1], requiring many to twist their left wrist. And this is why I hope the angle mod [2] from the Colemak community gets more mainstream recognition: instead of learning to twist your wrist, just shift the keys to let them adapt to you. This "un-kinks" the layout, allowing your left wrist to remain perfectly straight while your arm approaches the keyboard at a natural, relaxed angle like the person in the right side of the drawing.

[1] https://www.keybr.com/

[2] https://colemakmods.github.io/ergonomic-mods/angle.html