A patient being drunk wouldn’t make it any harder for me to anaesthetise them. But if they’re drunk they wouldn’t legally be able to confirm they consent to the anaesthetic immediately prior.

Given the multiplicative effect of sedatives and depressants, do you have to factor in inebriation, for instance for a DUI in the ER? Or are the safety margins sufficient?

Can you not consent to have something done to you while drunk, while you're sober beforehand? I mean you can sign beforehand to have surgery performed while you're knocked out, that's a bit more inebriated than most sorts of drunk.