As for coordinates, don’t forget galaxies are clouds of stars flowing around and interacting with each other.

That's the problem with address type of systems is that they expect the object at that location to always be at that location. How do you encode the orbital speed, radius of orbit for not just the object, but also the object it is orbiting will need the same info as it is also in motion, then that object's parent galaxy's motion. Ugh, now I need a nap to calm down a bit.