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mgraczyk 2 hours ago

Doctors here are cognitively captured by a system designed to limit cost (and that's mostly a good thing)

But scanning frequently is overwhelmingly good for the patient. The problem is the doctors. Imagine two possibilities. 1. You scan every six months and a doctor reviews your scans but never tells you anything no matter what 2. You scan every six months and a doctor reviews your scans and only tells you results if you have an obviously growing mass that has a probability greater than 95% of being cancerous

Obviously #2 is better for the patient than #1, but #1 is equivalent to never testing if you ignore cost.

So the actual reason we don't have effect frequent scans combined with effective diagnostic techniques is cost, and doctors cope with this reality by saying clearly wrong things about "over diagnosis". It's a local minimum of the payer/provider dynamic that has nothing to do with scans per se.

lich_king 32 minutes ago | parent | next [-]

Why is it good for the patient? I think that to claim this, you'd need to show a difference in outcomes.

Here, you have a tool with a ~100% false positive rate, so if we start administering it to everyone, it will almost certainly cost lives. Botched biopsies, unnecessary treatments, other complications. Not to mention the huge cost that would divert money from other welfare programs. So you need to show that when it actually detects something, it saves at least as many lives. And I doubt that's the case.

mgraczyk 30 minutes ago | parent [-]

Did you read my two options? Do you agree option 2 is better than option 1? If so, then scans are better than no scan

You don't need to show that it's possible to avoid false positives. That's doctors being irrational.

You only need to show that it's possible to build a diagnostic system that's better than no testing, and I have shown that already

lich_king 17 minutes ago | parent [-]

No. To argue for the benefit of the procedure, you need to show a difference in outcomes. Not that it can detect something, even if it could (which whole-body MRIs clearly don't). That the detection improves your chances of survival.

If you have an growing mass in your body, then if it's cancer, after a year, it might be too late for treatment. Or it may turn out to be nothing: a benign tumor / cyst / fat deposit in an unusual place. Or it may be slow-growing prostate cancer that you can live with for another 20 years, and maybe it's the chemotherapy that will do you in. It's really not that clear-cut in medicine.

To give you have another example: let's say that the risk of appendicitis in people who have an appendix is 1%. And the risk in people who had an appendix removed is 0%. Does this justify proactively removing the appendix? No, because the consequences of complications are much higher than the harm you're preventing. The same applies here: detection, even if 100% accurate, doesn't mean anything. You need to show that what you do with the result actually helps.

mgraczyk 11 minutes ago | parent [-]

The difference in out come is

With my change: 95% of people who are shown scans have cancer and are treated earlier. 5% of people do not have cancer and get CT scans. 0.5% of people get useless biopsies Without my change: many of those 95% die, the 0.5% do not get useless biopsies

And the beauty of this is you can pick the percentage!

> If you have an growing mass in your body, then after a year, it may very well no longer make a difference whether you treat it or not. Or it may be that you would have lived another 20 years just fine

This is just wrong for many parts of the body. In your brain? Your lungs? Growing for a year between 3 scans 6 months apart? Extremely unlikely to be benign

> The same applies here: detection, even if 100% accurate, doesn't mean anything. You need to show that what you do with the result actually helps.

This is wrong. If you had a 100% accurate cancer detector, fewer people would die of cancer with no downside

skywalqer 21 minutes ago | parent | prev [-]

Best comment here