That's a great question; it's something I still need to explore, but it would involve some sort of distributed public key database and IP address directory, then a routing table on top of that as people add more resources to the mesh. Wireguard is particularly good at transparent roaming, so it's trivial to use on portable devices or if you need to migrate your server from one provider to another.

Isn't this just Tailscale? Or Netmaker maybe if you want your own control plane?