To expand on that: B5 is about ethics, and it has a primordial good and evil that are decidedly kept in the mystical realm. It has a supernatural concept of souls, it has messiah-like characters, it seems to believe in a notion of fate. TNG on the other hand is steeped in renaissance enlightenment, it has the spirit that there is no supernatural, and that everything is rationally explainable. It often tackles ethics as well, but I dare say that beyond that it explores a broader territory in philosophical topics than B5. TNG is more down-to-earth, B5 is more vibe-heavy.