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abainbridge 3 hours ago

Yep, I think it is. The point is there's almost no history of oral peptides, other than stomachs destroying them.

FTA: "So to summarize the state of the art in oral peptide delivery: there are exactly two FDA-approved products that use permeation enhancers to get peptides into your bloodstream through your GI tract. Both achieve sub-1% bioavailability. Both required over a decade of development, thousands of clinical trial participants, and hundreds of millions of dollars."

pstuart 2 hours ago | parent [-]

Would a sublingual dose be possible/more effective? Research in other (um, yeah, medicinal!) compounds shows that it can be an effective pathway to the bloodstream rather than trying to survive the digestive system.

CGMthrowaway an hour ago | parent | next [-]

Sublingual is even harder. The sublingual mucosa is thin but selective. It strongly favors molecules that are small, lipophilic and uncharged. Semaglutide is about 8-10x too big, highly polar and charged.

Injection is really the only method with any substantial bioavailability. BUT, low (<1%) bioavailability does not necessarily mean useless.

cassepipe 20 minutes ago | parent [-]

> BUT, low (<1%) bioavailability does not necessarily mean useless.

Can you say more about that point ?

rodarmor 2 hours ago | parent | prev [-]

It would be hilarious if people wound up snorting or boofing their GLP-1s (≧▽≦)

40 minutes ago | parent | next [-]
[deleted]
pstuart 34 minutes ago | parent | prev [-]

Insufflation for medicinal purposes if it works and doesn't cause harm seem like a win. Less needles == more use.