Bezos has been pushing manufacturing-in-space for a long time, as a ideal candidate for what to do in space that you might prefer to not do on Earth. Robotics, AI automation, manufacturing - combo it in space, let the robots manufacture for us in space. Abundant energy, low concerns about most forms of pollution. We'll need to dramatically improve our ability to transit mass to and from cheaply first of course (we're obviously talking many decades into the future).

That is a fun thought experiment, as we wouldn't want to manufacture too far away from earth we may still be within the earth's atmosphere. I wonder what effect dumping greenhouse gases into the very upper levels of the atmosphere would have in comparison to doing it lower down. My assumption is it would eventually sink to a lower density layer, having more or less the same impact.