The problem with antidepressants are that while we know, more or less, what they do, we don't know why they work for some and not for others. Escitalopram (Lexapro) was a vast improvement for me over Citalopram. Then it plateaued and a year later, left me anhedonic. Tried an SNRI that would give me brain zaps every day a few hours before my next dose and it was horrendous to quit using. It also messed with my ability to meditate for a long while. Basically, I could put myself in a mental state that would trigger the same kind of painful brain zaps that withdrawal from the SNRI caused.