Yes. Made me manic. You know we make niacin in our own bodies, from tryptophan, down the kynurenine pathway. Sine many of the enzymes that are in this pathway need B6 and B2, being low in these may lower endogenous niacin in the body.

https://www.researchgate.net/publication/353319033/figure/fi...

Many people I know, when tested, were low in B6. That is more important to me than niacin.

For others who want to try this, taking too much B6 is associated with nerve damage - https://en.wikipedia.org/wiki/Megavitamin-B6_syndrome