I can't comment generally but I use NixOS and have had no issues playing games on Steam. The setup was laughably simple, just `programs.steam.enable = true;` and Steam handles compatibility so well that I buy games without thinking "will this run".

Actually there was one thing I couldn't do but this isn't unique to NixOS. I tried to install a GTAV mod that allows you to ride your smart bike trainer in game: GTBikeV. The mod can be installed, but the Bluetooth doesn't work. This is a WINE limitation.