Often not a dealbreaker, actually! We can spin up new tpuf regions and procure dedicated interconnects to minimize latency to the on-prem network on request (and we have done this).

When you're operating at the 100B scale, you're pushing beyond the capacity that most on-prem setups can handle. Most orgs have no choice but to put a 100B workload into the nearest public cloud. (For smaller workloads, considerations are different, for sure.)