There's a big gulf between being wrong because you or a collaborator missed an uncontrolled confounding factor and falsifying or altering results. Science accepts that people sometimes make mistakes in their work because a) they can also be expected to miss something eventually and b) a lot of work is done by people in training in labs you're not directly in control of (collaborators). They already aim for quality and if you're consistently shown to be sloppy or incorrect when people try to use your work in their own.

The final bit is a thing I think most people miss when they think about replication. A lot of papers don't get replicated directly but their measurements do when other researchers try to use that data to perform their own experiments, at least in the more physical sciences this gets tougher the more human centric the research is. You can't fake or be wrong for long when you're writing papers about the properties of compounds and molecules. Someone is going to come try to base some new idea off your data and find out you're wrong when their experiment doesn't work. (or spend months trying to figure out what's wrong and finally double check the original data).