Milk-V Titan is a Mini-ITX RISC-V board that has support for UEFI with ACPI and SMBIOS, 1x M key PCIe Gen4 x16 slot with GPU support, 2x USB Type-C (though unfortunately not USB-C PD), and a 12V DC barrel jack.

What is the difference in performance?

Titan hw docs: https://milkv.io/docs/titan/getting-started/hardware

To add a 2x20 pin (IDE ribbon cable) interface like a Pi: add a USB-to-2x20 pin board, use an RP2040/RP2350 (Pi Pico (uf2 bootloader) over serial over USB or Bluetooth or WiFi; https://news.ycombinator.com/item?id=38007967