Yes. The constant full screen color flashing made Windows 8 not just unpleasant to use, I was unable to use it since I literally got migraines after using it for too long.

Click on a pdf? The whole screen turns bright red for a second before loading. Click on a Word file, same but blue. It was hell to use for people sensitive to flashing lights.

I got special permission at work to stick with Windows 7 longer than the rest of the company for medical reasons.