Why do we need to try anything? This comes down to individualism versus collectivism.

Besides, the logical consequence of the portion of my comment you highlighted is that the majority of GLP-1 patients will need to be on these drugs forever to maintain these benefits long-term. We have precisely one trial of 5+ years of patients taking liraglutide, and ~2 years for semaglutide. Some side effects and long-term consequences could be entirely unknown.

It's possible that there could be long term side effects that we don't know about, but given the number of people taking these drugs we would likely already have seen some indication of them. I guess we will find out!