I started a GLP-1 in October. I've been eating healthy and exercising for a decade, but I was still in the obese category and blood sugar tests indicated I was at the edge of pre-diabetes. If I pushed hard on calorie reduction or exercise, I could gain 10-20% improvement, but it seemed like that would always reverse itself when I'd hit an injury or got sick. I'm hitting my mid-40s and decided it was time for a drastic change. I could have continued yo-yo dieting or opt for a solution that gets me to a healthy BMI within a year.

I gained a lot of weight during puberty, coupled with a less healthy diet in my youth. I suspect many folks are in the same boat - by the time they realize they need to eat/exercise, it's too late. Their metabolic system has been compromised by either diet, hormones, genetics, whatever.

In four months on a GLP-1, I've dropped about 18kg and since I coupled resistance training, I've increased on various strength parameters. The sudden reduction in weight has benefited my activity level substantially. There tends to be two classes of folks - those who need to stay on this drug forever and those who don't - I'm hoping in the end I fall into the don't, but I'm going to let the data from my continuous glucose monitor decide that.

I highly recommend the book "Ozempic Revolution" if you're considering the pros/cons of this path.

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93po 4 hours ago | parent [-]

> it's too late. Their metabolic system has been compromised by either diet, hormones, genetics, whatever.

I do want to be clear to anyone reading: there is no "too late". One's system does not become somehow damaged at some cliff of weight and eating habits. It doesn't become irreparably meaningfully physically more difficult to lose weight. What can happen is a shift in many systems that effectively make one feel hungry all the time and psychologically react very strongly to those hunger cues, which makes people eat more. Outside rare circumstances, if you eat less, you will lose weight. I do have a lot of compassion for the psychological side of things being extremely difficult, though.

	▲	sgwizdak 2 hours ago \| parent [-]
		Sorry - I think there's complexity with insulin at play that you're overlooking. When I did caloric restriction, I was constantly battling hypoglycemic events that made me not want to exercise. I don't get that with the GLP-1s. In online discussions, people tend to conflate GLP-1 with appetite suppressants - but there's also insulin stabilization that occurs.