I can't speak for DAWs but in 2019 when I tried switching to native Linux my Scarlett 2i2 3rd gen USB audio interface did not play nicely with Debian at the time. I'd get an endless amount of crackles and pops during recordings / playback and I spent days going over tons of audio configs / tools (Jack, Alsa, PulseAudio, etc.). They weren't xruns, at least Jack wasn't reporting them as that. Buffer sizes were normal too.

The good news is the same interface today works fine with PipeWire, without needing to tweak anything. I am using Arch this time around.

Yeah, these days the Scarletts are fine (as is the aging Firewire connected Edirol FA-101 I've got attached). Non-DAW things such as Supercollider work fine, but I focus less on that sort of environment (which isn't a dis - SC is great!).