In a word, yes. While Wine has been an option for decades, Valve and Proton have made gaming on Linux mainstream. You can check compatibility reports from https://www.protondb.com/ for whichever games you're interested in.

> Valve and Proton have made gaming on Linux mainstream.

"Mainstream" is maybe too hefty, the amount of Linux users (including SteamDeck) who participate in the Steam surveys are still in the single digit if I remember correctly. Most gamers today still use Windows, even though Valve made great strides with Proton.