Whoa, you can't post like this to HN, regardless of how wrong someone is or you feel they are.

We ban accounts that do this, and I'm afraid you've been breaking the site guidelines (https://news.ycombinator.com/newsguidelines.html) in other places as well, including other personal attacks: https://news.ycombinator.com/item?id=46530967.

It also looks like you've been using HN primarily for ideological battle, which is not something we allow here (see https://hn.algolia.com/?sort=byDate&dateRange=all&type=comme... for past explanations of this point).

Would you mind reviewing https://news.ycombinator.com/newsguidelines.html and sticking to the rules? We'd appreciate it. You're welcome here as long as you do that, but we really need commenters to stay respectful, avoid posting in the flamewar style, and (above all) use the site primarily for curiosity, not smiting enemies.

The "sequential treatment" or "tailored treatment" approach is at least plausible and what is done in practice, yes, if the prescribing doctor is good, and if this is feasible for the patient.

However, since this takes time, and most depression is temporary, it is hard to know if you really are tailoring the medication to the person in many cases, or it has just been long enough you are seeing regression to the mean (or a placebo response, which is still strong even in treatment-resistant depression https://jamanetwork.com/journals/jamanetworkopen/fullarticle...).

There aren't really any double-blinded or even just properly placebo-controlled / no-treatment controlled studies to test this, but the closest thing to looking at the sequential approach also doesn't find very impressive results (https://bmjopen.bmj.com/content/13/7/e063095.abstract).

I do believe the drugs help some people, and almost certainly take some experimentation / tailoring. The average effects are just very weak.

As a long time Usenetter, I don't care about the first two sentences being abrasive, but the material in quotes is insinuating that the replied-to grandparent at some point contained that verbatim text. I have a hunch that it did not, which is not cool. Particularly because the text is negative, making the false attribution defamatory, which is a different category from insults.

Please don't respond to a bad comment by breaking the site guidelines yourself. That only makes things worse.

https://news.ycombinator.com/newsguidelines.html

Pfizer ad or not I'll say my AD experience was positive. I got it prescribed by a psychiatric NP in a time when my job situation was about to go to hell but I was planning to tough it out till I got the project done.

I did get the sexual side effects but because men often come too quick it can be a blessing as much as a curse, personally I found it took longer to orgasm and when it did happen it was a much more complex and richer experience with a definite periodization I haven't had before or since.

When I was taking ADs I did have problems I blamed on the ADs that really had to do with the "non-drowsy" antihistamine I was taking crossing my blood brain barrier anyway.

When I did stop ADs I tapered over a month and the physical effects were not bad at all. It was the beginning of a time of personal growth that I can look back on now and think it worked out great but was challenging for the people around me for a while.