Huh? You reach towards the lens from the bottom left and thus a centered position puts a corner of the camera body in the way.

I had my directions reversed, so the extra reach doesn't really apply, I suppose, but I think aligned to the right side (when looking into the lens) is even worse. I maybe see what you mean about your hand hitting the body, but i actually want that; my grip has me resting the body along much of my left hand and cradled in my palm. That is really important to stability for me, it gives me an extra stop to work with.

All personal preference I guess!