Part of giving up is what is correct changes too fast. Attempts to do this manually often got great results for a year and then made things worse for the next generation of CPU that did things differently. Anyone who needs manual control thus would need to target a specific CPU and be willing to spend hundreds of millions every year to update the next CPU - there is nobody who is willing to spend that much. The few who would be are better served by putting the important thing into a FPGA which is going to be faster yet for similar costs.