Why not give up on high DPI?

Save money on the monitor, save money on the gpu (because it's pushing fewer pixels, you don't need as much oomph), save frustration with software.

4K monitors aren't a significant expense at this point, and text rendering is a lot nicer at 150% scale. The GPU load can be a concern if you're gaming but most newer games have upscalers which decouple the render resolution from the display resolution anyway.