I've been using this extensively recently. I was setting up remote virtual machines that boot a live ISO containing all the software for the machine. Sometimes I need to change a small config file, which would lead to generating a new 1.7GiB ISO, but 99.9% of that ISO is identical to the previous one. So I used rsync. Blew my mind when after a day of working on these images, uploading 1.7GiB ISO after 1.7GiB ISO, wireguard showed that I had only sent 600MiBs.

Fun surprise, rsync uses file size and modified time first to see if the files are identical. I build these ISOs with nix. Nix sets the time to Jan 1st 1970 for reproducible builds, and I suspect the ISOs are padded out to the next sector. So rsync was not noticing the new ISO images when I made small changes to config files until I added the --checksum flag.