This is just not true anymore. The only things that don't work anymore are a few AAA titles that use particular types of anti-cheat systems that rely on Windows kernel drivers (League of Legends is one that comes to mind).

If I remember correctly, after the Crowdstrike BSOD-all-windows-instances update last year Microsoft wanted to make some changes to their kernel driver program and these anti-cheat measures on Windows might need to find a new mechanism soon anyway. That's a long way of saying, it's plausible that even that last barrier might come down sooner rather than later.