In some games I get a crackle in the audio which I don't get through any native application, nor some games run with proton. I don't know if that's what he means, but it hasn't bothered me enough to figure it out. I use bluetooth headphones anyway, I'm relatively insensitive to audio fidelity.

If you run pw-top, you might see errors accumulating. This is usually due to an underrun from the game requesting an audio quantum that’s too low.

The fix is:

    mkdir -p ~/.config/pipewire/pipewire.conf.d && echo "context.properties = {default.clock.min-quantum = 1024}" | tee ~/.config/pipewire/pipewire.conf.d/pipewire.conf