Arguably monitors that are not mere TVs ought to allow control of each distinct pixel they drive internally and communicate their layout and if needed distinct brightness/color coordinates to the host.

Exceptions can apply if the consumers of the screen can't resolve details finer than "emulated sRGB pixels" anyways.

Something like that should be done in EDIDs may be, but you still would need to support a ton of different layouts in the end. LCD monitors are a lot more limited in that sense.