I really like the Python + Qt/pyside combination. I can whip together a rough GUI using QtCreator and then write the app logic in Python super quickly.

I’m sure it would be a goto if I made gui apps more regularly, because it’s clearly the more robust solution. So far wxglade is great for a drag-and-drop designer and the code is just enough closer to the regular Python way of doing things that it’s one less thing to learn.