There appears to be some danger in using NAD+ without the supervision of an experienced physician.

"Pieper emphasized that current over-the-counter NAD+-precursors have been shown in animal models to raise cellular NAD+ to dangerously high levels that promote cancer."

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digitaltrees 12 hours ago | parent | next [-]

Most people with Alzheimer’s are older and would probably trade having their cognitive abilities back even with increased risk of cancer

	▲	timr 10 hours ago \| parent [-]
		Depends entirely on the stage of the disease and the aggressiveness of the cancer! Getting an aggressive brain cancer when you had early stage Alzheimer’s [1] would be tragic. The tradeoff would be years of life. For the record, I have no idea what the actual risk tradeoff is, but the point of regulation is that nobody does. You can’t have informed consent when you can’t be informed. [1] Aside: Alzheimer’s is relatively early stage, as dementias go. It’s frequently diagnosed by onset in younger people.

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Aurornis 9 hours ago | parent | prev [-]

The chemical the parent comment linked is different.

NAD itself isn’t usually supplemented because it’s broken down by your digestive system. So NAD precursor supplements have been available for a while: NR and NMN specifically. These are the precursors they were talking about.

The actual drug used in this study has a different mechanism of action. It’s not directly available as a supplement, but like the parent commenter discovered you could technically find a chemical supply house to synthesize a tiny quantity of it.