Sadly, it's worse. We don't have one experiment that works in mice: we have dozens, if not hundreds. We've cured "Alzheimer's in mice" many times over. The treatments never work in humans, because it's not the same disease. We don't know the root cause of the human disease and so we can't model it accurately in mice.

> We don't know the root cause of the human disease

It's increasingly likely that there is no "root cause" to find in humans, but rather, that Alzheimer's is what happens when there's enough external stressors acting on the brain.

I've seen an analogy of a leaky roof being used: the leaks are things like age, stress, heavy metals, mold, bad sleep, bad diet. Genetics defines the original building materials (resilience) of the roof. You can put buckets under a certain number of leaks but if there are too many your ability to repair gets overwhelmed and the result is diseases like dementia.

I think something similar applies to other diseases of aging like heart disease, arthritis, osteoporosis, diabetes, perhaps even cancer.

The downside of this is that's it's hard to imagine a miracle drug being the solution. But the upside is that a combination therapy that identifies the "leaks" and works on reducing or eliminating them will likely be effective against a wide range of age related diseases.

The therapy will likely consist of drugs and supplements in combination with lifestyle changes.

I totally get that people are not mice, however animals studies have been useful for all sorts of diseases. Are they really uniquely bad for Alzheimer's?