So you might need some NAD+ precursor like NMN and this compound for it to work in humans because by the time you’re old it’s much harder for your body to make. Was the experiment done in older mice or younger ones that have NAD+ but artificial Alzheimer’s ?

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JumpCrisscross 15 hours ago | parent [-]

What’s the current state of between NMN, NR and straight-up niacin?

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storus 11 hours ago | parent [-]

NMN and NR are both good but NMN might not be available anymore as some company decided to repurpose it as a drug instead of supplement. Best combo nowadays looks to be liposomal NR with pterostilbene, a sirtuin activator. NR boosts NAD+ (the main electron transporter in mitochondria), pterostilbene activates sirtuin SIRT1 that regulates aging. B2/Riboflavin might be a good idea as well as it is a FADH donor, secondary electron transport carrier especially in nerves/brain. B1 to the mix as every single metabolic reaction needs it and it's depleted by consuming lots of carbs or drinking alcohol, a common western diet. Niacin is less effective in raising NAD+ but the flush can open up veins and flood hard to reach extremities of the body with blood so it's probably good from time to time. Slow B3 seems to be even worse for raising NAD+.

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JumpCrisscross 11 hours ago | parent [-]

> the flush can open up veins and flood hard to reach extremities of the body

What does it mean if I don’t flush? Is the supplement a dud?

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storus 11 hours ago | parent [-]

I know of three possible reasons:

- your supplement is a dud

- you took niacin too often (best to do it once a few days as body adapts quickly)

- you have a gene mutation that prevents you from absorbing enough B3 (common in some schizophrenia cases that can be managed by huge doses of daily B3, like 4-10g)

	▲	JumpCrisscross 10 hours ago \| parent [-]
		> you took niacin too often Oh yeah, I was taking it daily when I stopped flushing. Makes sense.