Accessibility is apparently a big problem with wayland. E.g., the most popular / ?only? app that supports hardware eye trackers on Linux does not work with wayland, and states that it likely never will as wayland does not provide what it needs to add support (it is also the most popular app for voice/noise control). Even basic things like screen readers are apparently still an issue with wayland. Without a strong accessibility story, systems running wayland would have been banned at my last employer (a college).

Personally, I have a 3200x2400 e-ink monitor that has a bezel that covers the outer few columns of pixels. I use a custom modeline to exclude those columns from use. And, a fractional scaling of .603x.5 on this now 3184x2400 monitor to get 1920x1200 effective resolution. Zero idea how to accomplish this with wayland-- I do not think it is possible, but if anyone knows a way, I am all ears.

I ran into, at least, ten issues without solutions/work-arounds (like the issue with my monitor) when I tried to switch this year, after getting a new laptop. Reverted to a functional, and productively familiar, setup with X.

I don't know about other DE, but at least with Plasma there is a "overscan" option to compensate for hidden borders.