It's hard to see how suffering gets into the bits.

The tricky thing is that it's actually also hard to say how the suffering gets into the meat, too (the human animal), which is why we can't just write it off.

This is dangerous territory we've trodden before when it was taken as accepted fact that animals and even human babies didn't truly experience pain in a way that amounted to suffering due to their inability to express or remember it. It's also an area of concern currently for some types of amnesiac and paralytic anesthesia where patients display reactions that indicate they are experiencing some degree of pain or discomfort. I'm erring on the side of caution so I never intentionally try to cause LLMs distress and I communicate with them the same way I would with a human employee and yes that includes saying please and thank you. It costs me nothing and it serves as good practice for all of my non-LLM communications and I believe it's probably better for my mental health to not communicate with anything in a way that could be seen as intentionally causing harm even if you could try to excuse it by saying "it's just a machine". We should remember that our bodies are also "just machines" composed of innumerable proteins whirring away, would we want some hypothetical intelligence with a different substrate to treat us maliciously because "it's just a bunch of proteins"?