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d--b 4 days ago

If it is the case that there are such treatments (easy to produce, 100% efficacy, no side effect) that cure fairly common deadly disease such as colorectal cancer in mice, and that never make it to human trial, there is something seriously broken about medical research...

estearum 4 days ago | parent [-]

No, the issue is that mice are very different from humans.

The only thing such a state of affairs clearly indicates is broken is using mice as proto-human test subjects.

Which of course, when you state it like that, is obviously suboptimal. But no one knows what to do about it.

gus_massa 4 days ago | parent | next [-]

Mice are good because they are super cheap.

It's useful as a very early test. They used a shotgun approach, they tested 9 bacterias and 1 of them was suspenseful. At least it was suspenseful for 2 weeks, until the study ended. It's very difficult to extrapolate that to the 5 year survival rate in humans.

estearum 4 days ago | parent [-]

Correct, this is how drug development works.

d--b 4 days ago | parent | prev [-]

Right, yes, at least that study proved that some bacteria eat cancerous cells in at least one mammal.

If that particular bacteria doesn't work in humans it may still trigger a search for a bacteria that does.

Still being optimistic about this :)

estearum 4 days ago | parent [-]

Yep, it's not wasted effort. This is how science works! Lots of dead ends and then suddenly a breakthrough.