This is an interesting analysis, and I like the sliders that let you instantly show the impacts of system trades.

The one glaring hole that I see is the challenge of moving the data to/from the datacenter while it's on orbit. Bandwidth to/from space isn't free. FCC/ITU licenses are required, transmitters/receiviers/modems/DSP/antennas all add to SWAP (size, weight, and power). Ground-stations are needed to move the data up/down, but those have recently become a commodity too. Still, they're not free. (see: https://aws.amazon.com/ground-station)

There is also the added latency between earth-based users and space-based datacenters, which may be a deal breaker for some applications.

Another issue I don't see covered are the significant differences between space-based hardware and terrestrial hardware. The space stuff needs to be radiation tolerant, and that usually makes it a lot slower and a lot more expensive than the terrestrial stuff, all other things being equal.

In the end, space-based datacenters are highly impractical even if you assume that Starship can put anything into orbit very cheaply.

The most chased workload will inevitably be cryptographic research, proofs of mathematical statements are hard to find the proof for, but tend to be short and easy to verify once a putative proof is presented. Just send the proofs back to earth.