I'm building a TypeScript to native code compiler, via the Dotnet CLR toolchain and Native AOT. This lets you use the excellent Dotnet std library - which in addition to being faster is also much safer than the npm ecosystem. There's also a node compat library, which exposes Node APIs but with CLR underneath.

The end result will be a binary (linux and mac for now) which you can run without NodeJS. Simple programs already work, and I have web apps very nearly running.