You can use so-called "exec magic" instead of `env -S`. Here is an explanation with Python examples: https://dbohdan.com/scripts-with-dependencies#exec-magic (disclosure: my site). In short:

  #! /bin/sh
  "exec" "/usr/bin/env" "uv" "run" "--quiet" "--script" "$0" "$@"
  # /// script
  # dependencies = [
  #   "cowsay",
  # ]
  # ///
  import cowsay
  cowsay.cow("Hello, world!")

  #! /bin/sh
  "exec" "/usr/bin/env" "pipx" "run" "$0" "$@"
  # ...