I'm sharing this more for folks who might have looked in a lot of places and are still seeking answers.

There has been a lot more science in this area it seems in the last 5 years, maybe it's just me, and the attention to do with long covid, or other things that cross the blood/brain barrier.

It's encouraging to see articles like this, since there is no single measure or signal of this, its really about considering brain health in general, and doing everything that is possible to eliminate neuroinflammation that can be.

The challenge for folks suffering with symptoms that includes a neurological thing like brain fog is the challenge of usually having to be the Quarterback integrating between specialists, because specialists don't necessarily integrate. For someone with cognitive fatigue, since it's differnet for everyone on different tasks, it can be a lot.

It's been eye opening to learn how many specialists first overlook proper neck posture and position since it can have a direct effect on what's getting into/out of the brain and downstream symptoms. Advocating for the basic inputs first before trying things is critical.

Additionally, tools like QEEG and FMRI are promising, not super mainstream yet but appear to have decent information it can provide of what is happening in the brain. In addition to this, the area of neurofeedback (devices like mendi, bellabee, etc seem to have some promise to help in some cases).

Another thing that too often gets missed is first ensuring things are OK physiologically. A simple xray of the neck and where nerves, blood and more go up into the brain is too often a step that's missed, and quite often there might be some compression, tightness or pinches there limiting the brain to recieve what it normally may have - and instead effort is spent trying to figure out how to get the brain operating better with a garden hose that's been slightly pinched.

Fatigue to the extent I understand it neurologically seems to at least two sided dice: energy and nutrition being available when and where it's needed on one side, and the things needed in place to use that energy effectively.

Chronic depletion or deficiencies in certain vitamins, amino acids, etc can also build up over time. Doing what we can for nutrition is critical, including any research backed neuroinflammation reducing supplements (magnesium threonate, saffron, omega 3, tumeric, etc).