This is a very popular theme, unfortunately without any practical conclusion.

I believe the practical conclusion is right there and pretty simple: if so, as long as we can't break out of this open world simulation and/or decisively prove we are in one, the best we can do is aim for success in the simulation. Just like we should do in the non-simulated world.

So, practically, we should behave the same.

Read the Bible. Conclusion seems very clear: We need strong men to fight invading demons, or we are doomed.