As someone who always avoids four-wheeled cages if possible, I can say highways are more or less safe if you have a fast enough motorcycle, compared to slow lane filtering with big vehicles on the road. Tiny spaces, poor visibility, and things that crush you on a slighest mistake is a dangerous combination.

If you look at the "motorcycling countries" (SEA, India/Pakistan, Africa, Latin America, etc.), most terrible accidents happen because trucks share the road with an army of scooters. I've been to a few of them on a motorcycle and it's a nightmare. For the same reason, big cities in China introduced dedicated scooter lanes separated by concrete barriers.