Netskope and the other DLP tools at my last gig would completely lock up my network connection for around 30 seconds every hour or two while maxing out 100% of a core. Fun times. The issue was still there a year after I first encountered it so I have grave doubts about the competence of those vendors.

On the other hand I am sympathetic to the needs of big regulated orgs to show they're doing something to avoid data loss. It's a painful situation.