That's very different from what I thought you were arguing for in your top comment, though: a computer-use agent proving the app is usable through a screen reader alone (and hopefully caching a replayable trace to not prompt it on every run).

Guidepup already exists, if people cared they'd use it for tests with or without LLMs. Thanks for showing me this tool BTW! I agree testing against real readers is better than using a third-party's heuristics.